Bactericidal effects of bioactive glasses on clinically important aerobic bacteria

  title={Bactericidal effects of bioactive glasses on clinically important aerobic bacteria},
  author={Eveliina Munukka and Outi Lepp{\"a}ranta and Mika Korkeamaeki and Minna Vaahtio and Timo Peltola and Di Zhang and Leena Hupa and Heimo O. Yl{\"a}nen and Jukka I Salonen and Matti K. Viljanen and Erkki Eerola},
  journal={Journal of Materials Science: Materials in Medicine},
Bioactive glasses (BAGs) have been studied for decades for clinical use, and they have found many dental and orthopedic applications. BAGs have also been shown to have an antibacterial effect e.g., on some oral microorganisms. In this extensive work we show that six powdered BAGs and two sol–gel derived materials have a clear antibacterial effect on 29 clinically important bacterial species. We also incorporated a rapid and accurate flow cytometric (FCM) method to calculate and standardize the… Expand
Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro
This large-scale study shows that two bioactive glass powders and a sol–gel derived material have an antibacterial effect on 17 clinically important anaerobic bacterial species. Expand
Antibacterial effect of bioactive glass nanoparticles prepared via sol gel method
Background: Infection constitutes the most important complication caused by biomaterials. Bioactive glasses have properties such as osteoconductivity and good restorability, some of which haveExpand
Antibacterial effect of a new bioactive glass on cariogenic bacteria.
Results from counting the CFU indicated that HX-BGC had stronger antibacterial effect when compare to SG, which is consistent with the SEM and CLSM results. Expand
Study on antibacterial effect of 45S5 Bioglass®
The results suggested that both the high pH and bioglass debris on the surface of bacteria may be the possible mechanisms of the antibacterial effect of 45S5 BAG particulates. Expand
Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review
The use of bioactive glass might be a promising solution for the reconstruction of bone defects, as well as for the treatment and eradication of bone infections, characterized by bone necrosis and destruction of the bone structure. Expand
Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on aerobic bacteria.
It was concluded that bioactive glass nanopowders could be considered as good candidates for the treatment of oral bone defects and root canal disinfection. Expand
Evaluation of the antibacterial and cytotoxic activity of gallium doped bioactive glass versus 45S5 Bioglass
In the healthcare setting, approximately 2 million bioinert devices are implanted into patients on an annual basis. However, interfacial instability of bioinert implants leads to reduced implantExpand
The in vitro antibacterial effect of S53P4 bioactive glass and gentamicin impregnated polymethylmethacrylate beads.
As a biocompatible and biodegradable bone substitute, S53P4 bioactive glass can be a good alternative in the local management of osteomyelitis and showed an antibacterial effect on all studied bacteria. Expand
Antibacterial Properties of Bioactive Glasses
Nanosized bioactive glasses, ion and natural organic substances and blended/doped bioactive glasses have been gaining growing attention due to their superior osteoconductivity and antibacterialExpand
The influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass.
The results of this current study suggest that the mechanism of antibacterial activity of Bioglass(®) is associated with changes in the environmental pH; an environment that is less likely to occur in vivo due to buffering of the system. Expand


Antibacterial activity of particulate bioglass against supra- and subgingival bacteria.
It was found that the viability of S. sanguis was significantly reduced following exposure to NB pre-incubated with Bioglass, and neutralisation of this highly alkaline solution eliminated the antibacterial effect. Expand
Antimicrobial effects of glass ionomer cements containing bioactive glass (S53P4) on oral micro-organisms in vitro
Commercial available GICs and GIC disks containing 30 wt% of BAG exerted antibacterial effects on S. mutans and C. albicans, the first time that this effect has been demonstrated for C.Albicans. Expand
Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model.
Subgingivally-modelled mixed species biofilms grown on particulate Bioglass have the potential to reduce bacterial colonisation of its surface in vivo, a feature relevant to post-surgical periodontal wound healing. Expand
Antibacterial effects of a bioactive glass paste on oral microorganisms.
In aqueous solutions the powdered bioactive glass S53P4 appears to have a broad antimicrobial effect on microorganisms of both supra- and subgingival plaque, which could be useful as an ingredient in tooth-care products that may have beneficial effects on oral health both from a cariologic and a periodontal point of view. Expand
Preliminary evaluation of bioactive glass S53P4 as an endodontic medication in vitro.
Standardized bovine dentin blocks infected with Enterococcus faecalis were treated with an aqueous calcium hydroxide or bioactive glass S53P4 (BAG) powder suspension and the BAG suspension eliminated the infection in the sampled dentin layers after 5 days. Expand
In Vitro Attachment of Staphylococcus Epidermidis to Surgical Sutures with and without Ag-Containing Bioactive Glass Coating
This preliminary study has demonstrated the quantification and visualization of bacterial attachment onto sutures in order to compare the antibacterial properties of Ag-containing bioactive glass coatings. Expand
Quantitative evaluation of antibacterial activities of metallic oxide powders (ZnO, MgO and CaO) by conductimetric assay.
  • J. Sawai
  • Chemistry, Medicine
  • Journal of microbiological methods
  • 2003
CaO was the most effective, followed by MgO and ZnO, against E. coli, and was suggested to have a strong affinity to the cells of S. aureus. Expand
Effect of mixing ratio on bactericidal action of MgO–CaO powders
From the results of bactericidal tests for Staphylococcus aureus, it was found that the bactericidal effect increased with the increase of CaO content in the samples. Expand
Antibacterial and bioactive silver-containing Na2O·CaO·2SiO2 glass prepared by sol–gel method
High antimicrobial effects of samples against Escherichia coli and Streptococcus mutans were found and FTIR measurements and SEM micrographs have ascertained the formation of a hydroxyapatite layer on the surface of samples soaked in a simulated body fluid for different times. Expand
Direct chemical bond of bioactive glass-ceramic materials to bone and muscle.
The objective of this research is to achieve direct chemical bonding of structurally strong implant materials with hard and soft tissues. This objective has been achieved through the development of aExpand