Bactericidal effects of bioactive glasses on clinically important aerobic bacteria

  title={Bactericidal effects of bioactive glasses on clinically important aerobic bacteria},
  author={Eveliina Munukka and Outi Lepp{\"a}ranta and Mika Korkeamaeki and Minna Vaahtio and Timo Peltola and Di Zhang and Leena Hupa and Heimo O. Yl{\"a}nen and Jukka I Salonen and Matti K. Viljanen and Erkki Eerola},
  journal={Journal of Materials Science: Materials in Medicine},
Bioactive glasses (BAGs) have been studied for decades for clinical use, and they have found many dental and orthopedic applications. BAGs have also been shown to have an antibacterial effect e.g., on some oral microorganisms. In this extensive work we show that six powdered BAGs and two sol–gel derived materials have a clear antibacterial effect on 29 clinically important bacterial species. We also incorporated a rapid and accurate flow cytometric (FCM) method to calculate and standardize the… 

Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro

This large-scale study shows that two bioactive glass powders and a sol–gel derived material have an antibacterial effect on 17 clinically important anaerobic bacterial species.

Antibacterial effect of bioactive glass nanoparticles prepared via sol gel method

These bioactive glass nanopowders can be regarded as good candidates in orthopedic application for the treatment of bone and dental defects but need supplementary and more evaluation considering their antibacterial effect on two important bacteria.

Study on antibacterial effect of 45S5 Bioglass®

The results suggested that both the high pH and bioglass debris on the surface of bacteria may be the possible mechanisms of the antibacterial effect of 45S5 BAG particulates.

Comparison of antibacterial and antibiofilm activity of bioactive glass compounds S53P4 and 45S5

It is found that 45S5 seems to be as effective as S53P4 and possibly even more capable of limiting bacterial infections, and the efficacy of bioactive glass was not limited to inhibition of planktonic growth, as it also extended to bacterial biofilms.

Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review

The use of bioactive glass might be a promising solution for the reconstruction of bone defects, as well as for the treatment and eradication of bone infections, characterized by bone necrosis and destruction of the bone structure.

Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on aerobic bacteria.

It was concluded that bioactive glass nanopowders could be considered as good candidates for the treatment of oral bone defects and root canal disinfection.

Evaluation of the antibacterial and cytotoxic activity of gallium doped bioactive glass versus 45S5 Bioglass

Results of the current work illustrated that 3 mol% gallium doped bioactive glass behaves in a similar manner to 45S5 Bioglass®, which is of interest for biological and tissue engineering applications.

The in vitro antibacterial effect of S53P4 bioactive glass and gentamicin impregnated polymethylmethacrylate beads.

As a biocompatible and biodegradable bone substitute, S53P4 bioactive glass can be a good alternative in the local management of osteomyelitis and showed an antibacterial effect on all studied bacteria.

Antibacterial Properties of Bioactive Glasses

This chapter presents the available methods for the preparation of these materials, their application, type of bioactive glasses, factors that play a vital role in enhancing their antibacterial properties against various bacterial traits and a brief detail of techniques applied to carry out antibacterial studies of nanosizedBioactive glasses.



Antimicrobial effects of glass ionomer cements containing bioactive glass (S53P4) on oral micro-organisms in vitro

Commercial available GICs and GIC disks containing 30 wt% of BAG exerted antibacterial effects on S. mutans and C. albicans, the first time that this effect has been demonstrated for C.Albicans.

Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model.

Subgingivally-modelled mixed species biofilms grown on particulate Bioglass have the potential to reduce bacterial colonisation of its surface in vivo, a feature relevant to post-surgical periodontal wound healing.

Antibacterial effects of a bioactive glass paste on oral microorganisms.

In aqueous solutions the powdered bioactive glass S53P4 appears to have a broad antimicrobial effect on microorganisms of both supra- and subgingival plaque, which could be useful as an ingredient in tooth-care products that may have beneficial effects on oral health both from a cariologic and a periodontal point of view.

Preliminary evaluation of bioactive glass S53P4 as an endodontic medication in vitro.

Standardized bovine dentin blocks infected with Enterococcus faecalis were treated with an aqueous calcium hydroxide or bioactive glass S53P4 (BAG) powder suspension and the BAG suspension eliminated the infection in the sampled dentin layers after 5 days.

In Vitro Attachment of Staphylococcus Epidermidis to Surgical Sutures with and without Ag-Containing Bioactive Glass Coating

This preliminary study has demonstrated the quantification and visualization of bacterial attachment onto sutures in order to compare the antibacterial properties of Ag-containing bioactive glass coatings.

Effect of mixing ratio on bactericidal action of MgO–CaO powders

From the results of bactericidal tests for Staphylococcus aureus, it was found that the bactericidal effect increased with the increase of CaO content in the samples.

Antibacterial and bioactive silver-containing Na2O·CaO·2SiO2 glass prepared by sol–gel method

High antimicrobial effects of samples against Escherichia coli and Streptococcus mutans were found and FTIR measurements and SEM micrographs have ascertained the formation of a hydroxyapatite layer on the surface of samples soaked in a simulated body fluid for different times.

Direct chemical bond of bioactive glass-ceramic materials to bone and muscle.

The objective of this research is to achieve direct chemical bonding of structurally strong implant materials with hard and soft tissues. This objective has been achieved through the development of a