Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria.

  title={Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria.},
  author={Robert Eng and Frank Padberg and Sharon M. Smith and Elizabeth Tan and C. E. Cherubin},
  journal={Antimicrobial agents and chemotherapy},
  volume={35 9},
Antimicrobial agents are most often tested against bacteria in the log phase of multiplication to produce the maximum bactericidal effect. In an infection, bacteria may multiply less optimally. We examined the effects of several classes of antimicrobial agents to determine their actions on gram-positive and gram-negative bacteria during nongrowing and slowly growing phases. Only ciprofloxacin and ofloxacin exhibited bactericidal activity against nongrowing gram-negative bacteria, and no… CONTINUE READING
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