Bactericidal and cross-protective activities of a monoclonal antibody directed against Neisseria meningitidis NspA outer membrane protein.

@article{Cadieux1999BactericidalAC,
  title={Bactericidal and cross-protective activities of a monoclonal antibody directed against Neisseria meningitidis NspA outer membrane protein.},
  author={Nathalie Cadieux and Matthew Plante and Cl{\'e}ment R. Rioux and Jos{\'e}e Hamel and Bernard R. Brodeur and Denis Nicol{\'a}s Martin},
  journal={Infection and immunity},
  year={1999},
  volume={67 9},
  pages={
          4955-9
        }
}
The cross-bactericidal and cross-protective activities of a monoclonal antibody (MAb) named Me-7, which is directed against an antigenically highly conserved epitope on the meningococcal NspA protein, were studied. This MAb efficiently killed in vitro, in the presence of rabbit or human serum, 13 of 14 meningococcal strains tested, including 9 of 9, 2 of 3, and 2 of 2 strains of serotypes B, A, and C, respectively. MAb Me-7 also significantly reduced by more than 75% the levels of bacteremia… CONTINUE READING

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