Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2

@article{Santamaria2005BactericidalAA,
  title={Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2},
  author={Carlos A. Santamaria and Silda Larios and Steve Quir{\'o}s and Javier Pizarro-Cerd{\'a} and Jean Pierre Gorvel and Bruno Lomonte and Edgardo Moreno},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2005},
  volume={49},
  pages={1340 - 1345}
}
ABSTRACT The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake Bothrops asper, have been shown to reproduce the bactericidal activity of the parent protein. They combine cationic and hydrophobic-aromatic amino acids, thus functionally resembling the antimicrobial peptides of innate defenses. This study evaluated the antimicrobial and antiendotoxic… 

Fungicidal activity of a phospholipase-A2-derived synthetic peptide variant against Candida albicans.

TLDR
This peptide displays a broad-spectrum antimicrobial activity, in the absence of hemolytic activity, and the fungicidal action of pEM-2 against Candida can be partially inhibited by increasing concentrations of extracellular divalent cations, in agreement with its proposed membrane-permeabilizing mechanism of action.

Identification of the Molecular Determinants of the Antibacterial Activity of LmutTX, a Lys49 Phospholipase A2 Homologue Isolated from Lachesis muta muta Snake Venom (Linnaeus, 1766)

TLDR
This study describes for the first time the isolation of a Lys49 PLA2 from Lachesis snake venom and shows that peptides from specific regions of the sequence may constitute new sources of molecules with biotechnological potential.

Loxosceles gaucho Spider Venom: An Untapped Source of Antimicrobial Agents

TLDR
The data suggest that U1-SCRTX-Lg1a is a promising candidate for the development of new antibiotics that could help fight bacterial infections and represents an exciting discovery for Loxosceles spiders.

In Vitro Antiplasmodial Activity of Phospholipases A2 and a Phospholipase Homologue Isolated from the Venom of the Snake Bothrops asper

TLDR
Results suggest that B. asper PLA2 and its homologue have antiplasmodial potential and toxicity in mice showed the highest lethal effect in comparison to fractions V and VI.

Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: Phospholipase A2 and L-amino acid oxidase.

...

References

SHOWING 1-10 OF 46 REFERENCES

Bactericidal and endotoxin neutralizing activity of a peptide derived from Limulus antilipopolysaccharide factor.

TLDR
It is demonstrated that peptide LALF #28-54 retained the LPS-neutralizing and bactericidal biologic activity of LALf but failed to protect during overwhelming P aeruginosa bacteremia, perhaps due to short serum half-life.

Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom.

TLDR
BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom, was structurally and functionally characterized and displayed bactericidal activity and promoted the blockage of the neuromuscular contraction of the chick biventer cervicis muscle.

A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides.

  • R. KiniH. Evans
  • Biology, Chemistry
    International journal of peptide and protein research
  • 1989
TLDR
The concept of a cytolytic region is strongly supported by the existence of several natural and synthetic analogues of cy tolysins and by chemical modification studies of these cytolysins, and provides a new focus for cyto Lysin research.

Antibacterial agents based on the cyclic d,l-α-peptide architecture

TLDR
It is reported that six- and eight-residue cyclic d,l-α-peptides act preferentially on Gram-positive and/or Gram-negative bacterial membranes compared to mammalian cells, increase membrane permeability, collapse transmembrane ion potentials, and cause rapid cell death.

The outer membranes of Brucella spp. are resistant to bactericidal cationic peptides

TLDR
The results show that the core lipid A of Brucella LPS plays a major role in polycation resistance and that O-chain density also contributes significantly, and it is proposed that the features described above contribute to Bru cella resistance to the oxygen-independent systems of phagocytes.

Candidacidal Activities of Human Lactoferrin Peptides Derived from the N Terminus

TLDR
The main conclusions are that the first two arginines at the N terminus of hF are critical in the candidacidal activity of hLF(1-11) and that extracellular ATP is essential but not sufficient for the peptide to exert its candidACidal activity.

Design of a potent novel endotoxin antagonist.

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.

The role of antimicrobial peptides in animal defenses.

  • R. HancockM. G. Scott
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
It is proposed that cationic antimicrobial peptides, which are induced by LPS and are able to dampen the septic response of animal cells to LPS, have a role in feedback regulation of cytokine responses.