Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2

  title={Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2},
  author={Carlos A. Santamaria and Silda Larios and Steve Quir{\'o}s and Javier Pizarro-Cerd{\'a} and Jean Pierre Gorvel and Bruno Lomonte and Edgardo Moreno},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={1340 - 1345}
ABSTRACT The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake Bothrops asper, have been shown to reproduce the bactericidal activity of the parent protein. They combine cationic and hydrophobic-aromatic amino acids, thus functionally resembling the antimicrobial peptides of innate defenses. This study evaluated the antimicrobial and antiendotoxic… 

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