Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis.

  title={Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis.},
  author={Sandeep K Tyagi and Eric Nuermberger and Tetsuyuki Yoshimatsu and Kathryn E Williams and Ionel Rosenthal and Nacer Lounis and William R Bishai and Jacques H. Grosset},
  journal={Antimicrobial agents and chemotherapy},
  volume={49 6},
The nitroimidazopyran PA-824 has potent in vitro activity against Mycobacterium tuberculosis, a narrow spectrum of activity limited primarily to the M. tuberculosis complex, and no demonstrable cross-resistance to a variety of antituberculosis drugs. In a series of experiments, we sequentially characterized the activity of PA-824 in an experimental murine model of tuberculosis. The minimal effective dose was 12.5 mg/kg of body weight/day. The minimal bactericidal dose (MBD) was 100 mg/kg/day… CONTINUE READING


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