Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells.

@article{Dhillon2010BactericidalAO,
  title={Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells.},
  author={Jasvir Dhillon and Koen Andries and Patrick P J Phillips and Denis Anthony Mitchison},
  journal={Tuberculosis},
  year={2010},
  volume={90 5},
  pages={
          301-5
        }
}
The bactericidal activities of the diarylquinoline TMC207 in a liquid culture medium started with a bacteriostatic phase lasting about 7 days and then continued with a dose-related bactericidal phase. In comparison, its intra-cellular activity in primary mouse peritoneal macrophages (PM) and in the J774 macrophage-like cell line had little or no static phase so that the bactericidal kill was evident by 5-7 days presumably due to low bacterial ATP levels. Bactericidal activities in the three… CONTINUE READING
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