Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice.

@article{Ji1996BactericidalAO,
  title={Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice.},
  author={Baohong Ji and Evelyne G. Perani and C Petinom and Jacques H. Grosset},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 2},
  pages={
          393-9
        }
}
The bactericidal activities of 12 regimens with various combinations of new drugs (clarithromycin [CLARI], minocycline [MINO], and ofloxacin [OFLO]) and the standard antileprosy drugs, especially rifampin (RMP), were compared in nude mice with established Mycobacterium leprae infection. The longest duration of treatment was 24 weeks for intermittent (once every 4 weeks) therapy and 8 weeks for daily therapy. Bactericidal effects were monitored by titrating the proportion of viable M. leprae… CONTINUE READING
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