Bactericidal/permeability-increasing protein, a lipopolysaccharide-specific protein on the surface of human peripheral blood monocytes.

@article{Dentener1996Bactericidalpermeabilityincreasin,
  title={Bactericidal/permeability-increasing protein, a lipopolysaccharide-specific protein on the surface of human peripheral blood monocytes.},
  author={Mieke A. Dentener and Giulio Francot and Wim A. Buurman},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={173 1},
  pages={
          252-5
        }
}
Bactericidal/permeability-increasing protein (BPI), a cationic protein present in the azurophilic granule and on the surface of polymorphonuclear leukocytes, specifically interacts with lipopolysaccharide (LPS). This study demonstrates for the first time, using flow cytometry with specific anti-BPI monoclonal antibody (MAb), that human peripheral blood monocytes express BPI on their cell surface. The monocyte cell surface BPI was shown to bind to LPS, because binding of anti-BPI MAb 4E3 (which… CONTINUE READING
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