Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics.

  title={Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics.},
  author={Jennifer A. MacDiarmid and Nancy B. Mugridge and Jocelyn C Weiss and Leo Phillips and Adam L Burn and Richard P Paulin and Joel E Haasdyk and K. I. Dickson and Vatsala N. Brahmbhatt and Scott T. Pattison and Alexander C James and Ghalib Al Bakri and Rodney C Straw and Bruce W. Stillman and Robert M. Graham and Himanshu Brahmbhatt},
  journal={Cancer cell},
  volume={11 5},
Systemic administration of chemotherapeutic agents results in indiscriminate drug distribution and severe toxicity. Here we report a technology potentially overcoming these shortcomings through encapsulation and cancer cell-specific targeting of chemotherapeutics in bacterially derived 400 nm minicells. We discovered that minicells can be packaged with therapeutically significant concentrations of chemotherapeutics of differing charge, hydrophobicity, and solubility. Targeting of minicells via… CONTINUE READING
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