Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.

@article{Lee2015BacterialUM,
  title={Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.},
  author={Kyung-Ah Lee and Boram Kim and Jinhyuk Bhin and Do Hun Kim and Hyejin You and Eun-kyoung Kim and Sung-Hee Kim and J L Ryu and Daehee Hwang and Won-Jae Lee},
  journal={Cell host & microbe},
  year={2015},
  volume={17 2},
  pages={191-204}
}
Genetic studies in Drosophila have demonstrated that generation of microbicidal reactive oxygen species (ROS) through the NADPH dual oxidase (DUOX) is a first line of defense in the gut epithelia. Bacterial uracil acts as DUOX-activating ligand through poorly understood mechanisms. Here, we show that the Hedgehog (Hh) signaling pathway modulates uracil-induced DUOX activation. Uracil-induced Hh signaling is required for intestinal expression of the calcium-dependent cell adhesion molecule… CONTINUE READING
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