Bacterial transformation: distribution, shared mechanisms and divergent control

  title={Bacterial transformation: distribution, shared mechanisms and divergent control},
  author={Calum Johnston and Bernard Martin and Gwennaele Fichant and Patrice Polard and Jean-Pierre Claverys},
  journal={Nature Reviews Microbiology},
Natural bacterial transformation involves the internalization and chromosomal integration of DNA and has now been documented in ∼80 species. Recent advances have established that phylogenetically distant species share conserved uptake and processing proteins but differ in the inducing cues and regulatory mechanisms that are involved. In this Review, we highlight divergent and common principles that govern the transformation process in different bacteria. We discuss how this cumulative knowledge… 

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Regulation of competence for natural transformation in streptococci.

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Changes in natural transformation after salt adaptation

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Vibrio cholerae: Measuring Natural Transformation Frequency

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HtrA‐mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformation

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A series of observations made in Bacillus subtilis and Streptococcus pneumoniae led to the recent emergence of a picture of a unique, highly integrated machine localized at the cell poles, which is proposed to name the transformasome.

Cues and regulatory pathways involved in natural competence and transformation in pathogenic and environmental Gram-negative bacteria.

How environmental cues contribute to the initiation of competence in a subset of naturally transformable Gram-negative bacteria and how the complexity of the niche might dictate the fine-tuning of the competence window are summarized.

Why do bacteria engage in homologous recombination?

  • M. Vos
  • Biology
    Trends in microbiology
  • 2009

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