Bacterial toxin RelE induces apoptosis in human cells.

  title={Bacterial toxin RelE induces apoptosis in human cells.},
  author={T-A M Yamamoto and Kenn Gerdes and Alan Tunnacliffe},
  journal={FEBS letters},
  volume={519 1-3},
The bacterial protein RelE severely restricts prokaryotic cell growth, probably by acting as a global inhibitor of translation. It is ubiquitous in prokaryotes as part of the RelE-RelB toxin-antitoxin system, and may be activated by nutritional stress. When the relE gene from Escherichia coli was expressed inducibly in a human osteosarcoma cell line, it was shown to retard growth and to lead to cell death by apoptosis. RelE is therefore unusual among bacterial toxins in possessing broad… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Cryptic prophages as targets for drug development.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy • 2016
View 1 Excerpt

Hypothesis: type I toxin-antitoxin genes enter the persistence field-a feedback mechanism explaining membrane homoeostasis.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2016

Prokaryotic Toxin-Antitoxins

Springer Berlin Heidelberg • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…