Bacterial toxin RelE induces apoptosis in human cells.

@article{Yamamoto2002BacterialTR,
  title={Bacterial toxin RelE induces apoptosis in human cells.},
  author={T-A M Yamamoto and Kenn Gerdes and Alan Tunnacliffe},
  journal={FEBS letters},
  year={2002},
  volume={519 1-3},
  pages={191-4}
}
The bacterial protein RelE severely restricts prokaryotic cell growth, probably by acting as a global inhibitor of translation. It is ubiquitous in prokaryotes as part of the RelE-RelB toxin-antitoxin system, and may be activated by nutritional stress. When the relE gene from Escherichia coli was expressed inducibly in a human osteosarcoma cell line, it was shown to retard growth and to lead to cell death by apoptosis. RelE is therefore unusual among bacterial toxins in possessing broad… CONTINUE READING

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