Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal Paneth cell α-defensins.

@article{Menendez2013BacterialSO,
  title={Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal Paneth cell α-defensins.},
  author={Alfredo Menendez and B P Willing and Marinieve Montero and Marta Wlodarska and C. K. So and Ganive Bhinder and Bruce A Vallance and Brett B. Finlay},
  journal={Journal of innate immunity},
  year={2013},
  volume={5 1},
  pages={39-49}
}
Paneth cell α-defensins are antimicrobial peptides involved in the control of the intestinal microbiota and immunological homeostasis. In mice, they are encoded by multiple, highly homologous genes (Defa). The transcriptional activity of ileal Defa genes was studied in response to pharmacological and genetic perturbations of the intestinal environment of C57BL/6 mice. Defa gene transcription was sensitive to oral antibiotic administration suggesting that commensal microbes regulate Defa… CONTINUE READING
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