Bacterial signaling systems as platforms for rational design of new generations of biosensors.

@article{Checa2012BacterialSS,
  title={Bacterial signaling systems as platforms for rational design of new generations of biosensors.},
  author={Susana Karina Checa and Matias D. Zurbriggen and Fernando C Soncini},
  journal={Current opinion in biotechnology},
  year={2012},
  volume={23 5},
  pages={766-72}
}
Bacterial signal-responsive regulatory circuits have been employed as platform to design and construct whole-cell bacterial biosensors for reporting toxicity. A new generation of biosensors with improved performance and a wide application range has emerged after the application of synthetic biology concepts to biosensor design. Site-directed mutagenesis, directed evolution and domain swapping were applied to upgrade signal detection or to create novel sensor modules. Rewiring of the genetic… CONTINUE READING
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