Bacterial sigma factors: a historical, structural, and genomic perspective.

  title={Bacterial sigma factors: a historical, structural, and genomic perspective.},
  author={Andrey Feklistov and Brian D Sharon and Seth A Darst and Carol A. Gross},
  journal={Annual review of microbiology},
Transcription initiation is the crucial focal point of gene expression in prokaryotes. The key players in this process, sigma factors (σs), associate with the catalytic core RNA polymerase to guide it through the essential steps of initiation: promoter recognition and opening, and synthesis of the first few nucleotides of the transcript. Here we recount the key advances in σ biology, from their discovery 45 years ago to the most recent progress in understanding their structure and function at… CONTINUE READING
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