Bacterial resistance to silver nanoparticles and how to overcome it

@article{Panacek2017BacterialRT,
  title={Bacterial resistance to silver nanoparticles and how to overcome it},
  author={Ales Panacek and Libor Kv{\'i}tek and Monika Smekalova and Renata Vecerova and Milan Kol{\'a}ř and Magdal{\'e}na R{\"o}derov{\'a} and Filip Dycka and Marek {\vS}ebela and Robert Prucek and Ondřej Tomanec and Radek Zbořil},
  journal={Nature Nanotechnology},
  year={2017},
  volume={13},
  pages={65-71}
}
Silver nanoparticles have already been successfully applied in various biomedical and antimicrobial technologies and products used in everyday life. Although bacterial resistance to antibiotics has been extensively discussed in the literature, the possible development of resistance to silver nanoparticles has not been fully explored. We report that the Gram-negative bacteria Escherichia coli 013, Pseudomonas aeruginosa CCM 3955 and E. coli CCM 3954 can develop resistance to silver nanoparticles… 
Does Silver in Different Forms Affect Bacterial Susceptibility and Resistance? A Mechanistic Perspective.
TLDR
The obtained results support the reservoir nature of nanoparticles for the controlled release of silver ions into bacteria and provide valuable insight on the mechanism of silver resistance and antibacterial strategies deployed by E. coli K12, which could be a potential target for the generation of aim-based and effective nanoantibiotics.
Escherichia coli Bacteria Develop Adaptive Resistance to Antibacterial ZnO Nanoparticles
TLDR
It is reported that Escherichia coli develops adaptive resistance to antibacterial ZnO NPs after several days' exposure to the NPs, and it is suggested that the observed resistance is caused by changes in the shape of the bacteria and the expressions of membrane proteins.
Silver Covalently Bound to Cyanographene Overcomes Bacterial Resistance to Silver Nanoparticles and Antibiotics
TLDR
GCN/Ag shows that rigid supports selectively and densely functionalized with potent silver‐binding ligands, such as cyanographene, may open new avenues against microbial resistance.
Superior Bactericidal Efficacy of Fucose-Functionalized Silver Nanoparticles against Pseudomonas aeruginosa PAO1 and Prevention of Its Colonization on Urinary Catheters.
TLDR
The present work strongly advocates the use of antivirulence targets and their corresponding binding residues for the augmentation of the bactericidal effect of silver nanoparticles.
Role of bacterial motility in differential resistance mechanisms of silver nanoparticles and silver ions
TLDR
Bacterial motility may be used as an important predictor of whether a particular bacteria strain can develop AgNP resistance and could inform design of nanoenabled antimicrobials that mechanistically target specific types of bacteria.
Metallic Nanoparticles—Friends or Foes in the Battle against Antibiotic-Resistant Bacteria?
TLDR
It is pointed out that careful management of these very promising antimicrobials is necessary to preserve their efficacy for infection control and the adverse side effects that bacterial exposure to nanoparticles may have on antibiotic resistance dissemination.
Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria
TLDR
Despite ample evidence of heavy metal resistance in this bacterium, little research has been dedicated to assessing the potential for NAg resistance development in A. baumannii, which is worrisome, as the increasingly indiscriminate use of NAg could promote the development of silver resistance inThis species, like what has occurred with antibiotics.
Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics
TLDR
This study presents a promising strategy with further testing in vivo, to develop novel antimicrobial agents and strategies to confront emerging antimicrobial resistance.
Antimicrobial Resistance and Inorganic Nanoparticles
TLDR
This work aims to give a general vision between the antibiotics, the nanoparticles used as carriers, bacteria resistance, and the possible mechanisms that occur between them to improve drug potency by reducing overall antibiotic exposure.
Impact of Biosynthesized Silver Nanoparticles on Bacterial Growth
TLDR
The researcher’s work primarily focused on determining how effective silver nanoparticles produced by different bacterial species were at inhibiting bacterial growth, and indicated that silver nanoparticle produced by B. subtilis were the most effective in inhibitingacterial growth.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria
TLDR
The data suggest that silver nanoparticles are effective broad-spectrum biocides against a variety of drug-resistant bacteria, which makes them a potential candidate for use in pharmaceutical products and medical devices that may help to prevent the transmission ofdrug-resistant pathogens in different clinical environments.
Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria
TLDR
This work shows that silver can be used to enhance the action of existing antibiotics against Gram-negative bacteria, thus strengthening the antibiotic arsenal for fighting bacterial infections.
Rapid evolution of silver nanoparticle resistance in Escherichia coli
TLDR
This study indicates that despite previous claims to the contrary bacteria can easily evolve resistance to AgNPs, and this occurs by relatively simple genomic changes, and care should be taken with regard to the use of eNPs as biocides as well as with regards to unintentional exposure of microbial communities to eNPS in waste products.
Antibacterial activity of silver nanoparticles: sensitivity of different Salmonella serovars
TLDR
Results showed an immediate, time-limited and serovar-dependent reduction of bacterial viability in Salmonella Enteritidis, Hadar, and Senftenberg, suggesting the importance of a cautious use of AgNPs.
Antibacterial effect of silver nanoparticles on Staphylococcus aureus
TLDR
The antibacterial activity and mechanism of silver nanoparticles (Ag-NPs) on Staphylococcus aureus ATCC 6538P were investigated and the proteomic analysis showed that the expression abundance of some proteins was changed in the treated bacterial cell with Ag-Nps.
Strong and Nonspecific Synergistic Antibacterial Efficiency of Antibiotics Combined with Silver Nanoparticles at Very Low Concentrations Showing No Cytotoxic Effect
TLDR
A very low amount of silver is needed for effective antibacterial action of the antibiotics, which represents an important finding for potential medical applications due to the negligible cytotoxic effect of AgNPs towards human cells at these concentration levels.
Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus
TLDR
When AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.
Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins
TLDR
The results suggest that active efflux, presumably coded by a chromosomal gene(s), may play a major role in silver resistance, which is likely to be enhanced synergistically by decreases in OM permeability.
...
1
2
3
4
...