Bacterial resistance mechanisms against host defense peptides

  title={Bacterial resistance mechanisms against host defense peptides},
  author={Toma{\vz} Koprivnjak and Andreas Peschel},
  journal={Cellular and Molecular Life Sciences},
Host defense peptides and proteins are important components of the innate host defense against pathogenic microorganisms. They target negatively charged bacterial surfaces and disrupt microbial cytoplasmic membranes, which ultimately leads to bacterial destruction. Throughout evolution, pathogens devised several mechanisms to protect themselves from deleterious damage of host defense peptides. These strategies include (a) inactivation and cleavage of host defense peptides by production of host… CONTINUE READING
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