Bacterial persistence: some new insights into an old phenomenon

@article{Jayaraman2008BacterialPS,
  title={Bacterial persistence: some new insights into an old phenomenon},
  author={Rajshri Jayaraman},
  journal={Journal of Biosciences},
  year={2008},
  volume={33},
  pages={795-805}
}
Bigger discovered more than 60 years ago, at the very beginning of the antibiotic era, that populations of antibiotic-sensitive bacteria contained a very small fraction (approximately 10−6) of antibiotic-tolerant cells (persisters). Persisters are different from antibiotic-resistant mutants in that their antibiotic tolerance is non-heritable and reversible. In spite of its importance as an interesting biological phenomenon and in the treatment of infectious diseases, persistence did not attract… CONTINUE READING
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