Bacterial peptide chain release factors: conserved primary structure and possible frameshift regulation of release factor 2.

@article{Craigen1985BacterialPC,
  title={Bacterial peptide chain release factors: conserved primary structure and possible frameshift regulation of release factor 2.},
  author={William J. Craigen and Richard G. Cook and Warren P. Tate and C. Thomas Caskey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 11},
  pages={3616-20}
}
Escherichia coli peptide chain release factors are proteins that direct the termination of translation in response to specific peptide chain termination codons. The mechanisms of codon recognition and peptidyl-tRNA hydrolysis are unknown. We have characterized the genes encoding release factor 1 (RF-1) and release factor 2 (RF-2) to study the structure-function relationships of the proteins and their regulation in the bacterium. In this report, we present the gene structure of RF-1 and RF-2… CONTINUE READING