Bacterial natural products in the fight against mosquito-transmitted tropical diseases.

@article{Saraiva2019BacterialNP,
  title={Bacterial natural products in the fight against mosquito-transmitted tropical diseases.},
  author={Ra{\'u}l G Saraiva and George Dimopoulos},
  journal={Natural product reports},
  year={2019}
}
Covering: up to 2019Secondary metabolites of microbial origin have long been acknowledged as medically relevant, but their full potential remains largely unexploited. Of the countless natural compounds discovered thus far, only 5-10% have been isolated from microorganisms. At the same time, while whole-genome sequencing has demonstrated that bacteria and fungi often encode natural products, only a few genera have yet been mined for new compounds. This review explores the contributions of… 

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References

SHOWING 1-10 OF 198 REFERENCES

Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite

TLDR
It is shown that salinosporamide A protected mice against deadly malaria infection when administered at an extremely low dosage, underline the potential of secondary metabolites, derived from marine microorganisms, to inhibit Plasmodium growth.

Bioactive natural products from novel microbial sources

TLDR
This review highlights examples of bacteria that should be considered new sources of natural products, including anaerobes, pathogens, and symbionts of humans, insects, and nematodes, to open the way for a new golden age of microbial therapeutics.

Natural Products as Source of Potential Dengue Antivirals

TLDR
In this review, an assortment of natural products that have been reported as possessing dengue antiviral activity are described and organized into classes of substances.

The re-emerging role of microbial natural products in antibiotic discovery

TLDR
Different innovative approaches are defining a completely new framework that is setting the bases for the future discovery of novel chemical scaffolds that should foster a renewed interest in the identification of novel classes of natural product antibiotics from the microbial world.

Discovery of Potent Broad Spectrum Antivirals Derived from Marine Actinobacteria

TLDR
The results provide conclusive validation for using natural product resources derived from marine microbes as source material for antiviral drug discovery, and they indicate that host mitochondrial electron transport is a viable target for the continued development of broadly active antiviral compounds.

Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities

TLDR
This bacterium isolated from the midgut of field-caught Aedes aegypti exerts in vitro anti-Plasmodium and anti-dengue activities, which appear to be mediated through Csp_P -produced stable bioactive factors with transmission-blocking and therapeutic potential.

Promising lead compounds for novel antiprotozoals

TLDR
HAT is fatal if left untreated, with treatment depending on the stage of the disease, and the swift development and introduction of safer, more effective, easy-to-use and affordable drugs will be instrumental in helping to achieve recent initiatives aimed at eliminating the disease as a public health problem.

Antimicrobial peptides of the genus Bacillus: a new era for antibiotics.

TLDR
This work focuses on Bacillus-derived AMPs as a novel alternative approach to antibacterial drug development and provides an overview of the biosynthesis, mechanisms of action, applications, and effectiveness of different AMPs produced by members of the Bacillus genus.

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

TLDR
The organic extract of a Schizothrix species from a tropical reef near Piedras Gallinas (Caribbean coast of Panama) showed potent initial antimalarial activity against the W2 chloroquine-resistant strain of Plasmodium falciparum.

Functional genomic analyses of Enterobacter, Anopheles and Plasmodium reciprocal interactions that impact vector competence

TLDR
Esp_Z is capable of inhibiting sporogonic development of Plasmodium in the presence of the mosquito’s native microbiota without affecting mosquito fitness and is able to induce a partial and temporary shutdown of the ookinetes antioxidant response.
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