Bacterial natural products in the fight against mosquito-transmitted tropical diseases.

  title={Bacterial natural products in the fight against mosquito-transmitted tropical diseases.},
  author={Ra{\'u}l G Saraiva and George Dimopoulos},
  journal={Natural product reports},
Covering: up to 2019Secondary metabolites of microbial origin have long been acknowledged as medically relevant, but their full potential remains largely unexploited. Of the countless natural compounds discovered thus far, only 5-10% have been isolated from microorganisms. At the same time, while whole-genome sequencing has demonstrated that bacteria and fungi often encode natural products, only a few genera have yet been mined for new compounds. This review explores the contributions of… 

Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions

This work provides a review of natural compounds endowed with blockade potential against transmissible forms of human pathogens reported in the last 2 decades from 2000 to 2021 and proposes various translational strategies that can exploit these pathogen transmission-blocking natural products into design of novel and sustainable disease control interventions.

Functional Food for the Stimulation of the Immune System Against Malaria

Recent knowledge on the role of the gut microbiota in malaria prevention and treatment is summarized and the search for lactic acid bacteria expressing α-Gal and those that exhibit the desired immune stimulating properties for the development of functional food and probiotics for malaria control is encouraged.

Symbiotic microbes from various seaweeds with antimicrobial and fermentative properties.

This study aims to determine the microbial species from some seaweeds through molecular identification using molecular identification method (PCR 16S rDNA) and collected from the waters of Bunaken, Northern Sulawesi using purposive sampling method.

Functional characterization of α-Gal producing lactic acid bacteria with potential probiotic properties

It is concluded that the lactic acid bacteria in this study producing α-Gal have potential probiotic capacity and can be further explored in α- Gal-focused research for both the prevention and treatment of various infectious diseases and probiotic development.

An Aedes aegypti seryl-tRNA synthetase paralog controls bacteroidetes growth in the midgut

This is the first time that the absence of a mitochondrial enzyme is linked to intestinal microbiota without any visible effects in mitochondrial respiration and mitochondrial ROS production and indicates that the intestinal microbiota can be controlled in a blood-feeding vector by a novel, unprecedent mechanism.

Considerations for mosquito microbiome research from the Mosquito Microbiome Consortium

The Mosquito Microbiome Consortium is established, a collaborative initiative for the advancement of mosquito microbiome research, whose overall goal is to collectively work on unraveling the role of the mosquito microbiome in mosquito biology, while critically evaluating its potential for mosquito-borne disease control.

Heme-induced genes facilitate endosymbiont (Sodalis glossinidius) colonization of the tsetse fly (Glossina morsitans) midgut

Tsetse flies (Glossina spp.) feed exclusively on vertebrate blood. After a blood meal, the enteric endosymbiont Sodalis glossinidius is exposed to various environmental stressors including high

Bioprospecting of Natural Compounds for Industrial and Medical Applications



Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite

It is shown that salinosporamide A protected mice against deadly malaria infection when administered at an extremely low dosage, underline the potential of secondary metabolites, derived from marine microorganisms, to inhibit Plasmodium growth.

Bioactive natural products from novel microbial sources

This review highlights examples of bacteria that should be considered new sources of natural products, including anaerobes, pathogens, and symbionts of humans, insects, and nematodes, to open the way for a new golden age of microbial therapeutics.

Natural Products as Source of Potential Dengue Antivirals

In this review, an assortment of natural products that have been reported as possessing dengue antiviral activity are described and organized into classes of substances.

The re-emerging role of microbial natural products in antibiotic discovery

Different innovative approaches are defining a completely new framework that is setting the bases for the future discovery of novel chemical scaffolds that should foster a renewed interest in the identification of novel classes of natural product antibiotics from the microbial world.

Discovery of Potent Broad Spectrum Antivirals Derived from Marine Actinobacteria

The results provide conclusive validation for using natural product resources derived from marine microbes as source material for antiviral drug discovery, and they indicate that host mitochondrial electron transport is a viable target for the continued development of broadly active antiviral compounds.

Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities

This bacterium isolated from the midgut of field-caught Aedes aegypti exerts in vitro anti-Plasmodium and anti-dengue activities, which appear to be mediated through Csp_P -produced stable bioactive factors with transmission-blocking and therapeutic potential.

Promising lead compounds for novel antiprotozoals

HAT is fatal if left untreated, with treatment depending on the stage of the disease, and the swift development and introduction of safer, more effective, easy-to-use and affordable drugs will be instrumental in helping to achieve recent initiatives aimed at eliminating the disease as a public health problem.

Antimicrobial peptides of the genus Bacillus: a new era for antibiotics.

This work focuses on Bacillus-derived AMPs as a novel alternative approach to antibacterial drug development and provides an overview of the biosynthesis, mechanisms of action, applications, and effectiveness of different AMPs produced by members of the Bacillus genus.

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

The organic extract of a Schizothrix species from a tropical reef near Piedras Gallinas (Caribbean coast of Panama) showed potent initial antimalarial activity against the W2 chloroquine-resistant strain of Plasmodium falciparum.

Functional genomic analyses of Enterobacter, Anopheles and Plasmodium reciprocal interactions that impact vector competence

Esp_Z is capable of inhibiting sporogonic development of Plasmodium in the presence of the mosquito’s native microbiota without affecting mosquito fitness and is able to induce a partial and temporary shutdown of the ookinetes antioxidant response.