Bacterial modification of LPS and resistance to antimicrobial peptides.

  title={Bacterial modification of LPS and resistance to antimicrobial peptides.},
  author={John S Gunn},
  journal={Journal of endotoxin research},
  volume={7 1},
  • John S Gunn
  • Published 2001 in Journal of endotoxin research
Antimicrobial peptides (APs) are ubiquitous in nature and are thought to kill micro-organisms by affecting membrane integrity. These positively charged peptides interact with negative charges in the LPS of Gram-negative bacteria. A common mechanism of resistance to AP killing is LPS modification. These modifications include fatty acid additions, phosphoethanolamine (PEtN) addition to the core and lipid A regions, 4-amino-4-deoxy-L-arabinose (Ara4N) addition to the core and lipid A regions… CONTINUE READING
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