Bacterial meningitis in children

@article{SezLlorens2003BacterialMI,
  title={Bacterial meningitis in children},
  author={Xavier S{\'a}ez-Llorens and George H. McCracken},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={2139-2148}
}
Microbiologic causes of meningitis include bacteria, viruses, fungi, and parasites. Before routine use of pneumococcal conjugate vaccine, bacterial meningitis affected almost 6000 people every year in the United States, and about half of all cases occurred in children 18 years old or younger. Prompt and accurate diagnosis and adequate treatment of bacterial meningitis in children remains a major challenge, as reflected by the continued high morbidity and case-fatality rates of the disease… Expand
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347 Citations
Highly Influential Citations
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347 Citations

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Bacterial meningitis.
TLDR
The epidemiology, pathophysiology, and management of bacterial meningitis is reviewed, including Dexamethasone therapy, which has been implemented as adjunctive treatment of adults with pneumococcalMeningitis. Expand
Bacterial meningitis in childhood.
TLDR
In the last two decades widespread introduction of highly effective conjugate vaccines against these pathogens in many industrialised countries has led to a significant reduction in the incidence of bacterial meningitis, although there is still a substantial global burden of disease. Expand
Bacterial meningitis in children.
This review comprises aspects of the epidemiology, microbiology, pathophysiology, clinical manifestations, diagnosis, management, prognosis, and prevention of bacterial meningitis, with emphasis on… Expand
Acute Bacterial Meningitis in Children
TLDR
Optimal management consists of rapid diagnosis and administration of bactericidal antibiotics with properties allowing adequate penetration of the inflamed blood-brain barrier. Expand
Bacterial meningitis in children.
TLDR
A significant reduction of the numbers of bacterial meningitis caused by Haemophilus influinzae type B species is found in children beyond the neonatal period. Expand
Paediatric meningitis: Clinical features and diagnosis
Despite successful vaccination campaigns in many parts of the world, bacterial meningitis in children remains a serious healthcare challenge. Worldwide, it is the cause of over 125,000 deaths every… Expand
Bacterial Meningitis
TLDR
Clinical studies have demonstrated the benefit of adjunctive dexamethasone in infants and children with Haemophilus influenzae type B meningitis, and adults with pneumococcal meneditis, in which mortality and adverse outcome are reduced. Expand
Meningitis in Children: Diagnosis and Treatment for the Emergency Clinician
TLDR
It is very important to maintain a high index of suspicion and a low threshold for evaluation of meningitis in febrile young infants younger than 3 months. Expand
Diagnosis, initial management, and prevention of meningitis.
TLDR
Empiric antimicrobial therapy based on age and risk factors must be started promptly in patients with bacterial meningitis and should not be delayed, even if a lumbar puncture cannot be performed because results of a computed tomography scan are pending or because the patient is awaiting transfer. Expand
Bacteremia in children: epidemiology, clinical diagnosis and antibiotic treatment
TLDR
A brief overview of the clinical diagnosis of bacteremia in children is provided, focusing on the epidemiology, clinical characteristics, risk factors, antibiotic treatment, outcomes and preventative measures to reduce the incidence of b acteremia and improve morbidity and mortality. Expand
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