Bacterial lysate (I.R.S. 19) applied intranasally in the prevention of acute respiratory diseases in children: a randomized double-blind study.

@article{Sramek1986BacterialL,
  title={Bacterial lysate (I.R.S. 19) applied intranasally in the prevention of acute respiratory diseases in children: a randomized double-blind study.},
  author={John Sramek and M Jos{\'i}fko and J Helcl and E Holoubkov{\'a} and Vladim{\'i}r Janout and B Kozesn{\'i}k and I Mac{\'a}tov{\'a}},
  journal={Journal of hygiene, epidemiology, microbiology, and immunology},
  year={1986},
  volume={30 4},
  pages={377-85}
}
A controlled trial was undertaken to test I.R.S. 19 (a commercial intranasal spray) versus placebo in the prevention of acute respiratory diseases (ARD) in 825 maternity-school children in three cities; another control group of 327 children received neither I.R.S. 19 nor placebo. The spraying was done twice a day for a total of 20 spraying days in each child; sprayings were interrupted on weekends and during absence, the mean spraying period being 34 calendar days. During the 6-month study (1… CONTINUE READING
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