Bacterial luciferase is naturally destabilized in Mycobacterium tuberculosis and can be used to monitor changes in gene expression.

@article{Roberts2005BacterialLI,
  title={Bacterial luciferase is naturally destabilized in Mycobacterium tuberculosis and can be used to monitor changes in gene expression.},
  author={Esteban A Roberts and Amanda K. Clark and Richard L. Friedman},
  journal={FEMS microbiology letters},
  year={2005},
  volume={243 1},
  pages={243-9}
}
Reporter systems efficient at monitoring temporal gene expression in slow-growing mycobacteria would significantly aid the characterization of gene expression in specific environments. Bacterial luciferase is a reporter that has not been widely used to study gene expression in mycobacteria. This report describes the determination of the degradation of bacterial luciferase in Mycobacterium tuberculosis H37Ra and its utility as a reporter of temporal gene expression in this slow-growing… CONTINUE READING