Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2.

@article{Power2004BacterialLD,
  title={Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2.},
  author={Colm P. Power and Jian Wang and Brian J. Manning and Malcolm R. Kell and Noel John Aherne and Qiong Di Wu and Henry Paul Redmond},
  journal={Journal of immunology},
  year={2004},
  volume={173 8},
  pages={5229-37}
}
The human sepsis syndrome resulting from bacterial infection continues to account for a significant proportion of hospital mortality. Neutralizing strategies aimed at individual bacterial wall products (such as LPS) have enjoyed limited success in this arena. Bacterial lipoprotein (BLP) is a major constituent of the wall of diverse bacterial forms and profoundly influences cellular function in vivo and in vitro, and has been implicated in the etiology of human sepsis. Delayed polymorphonuclear… CONTINUE READING
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