Bacterial lipoprotein biosynthetic pathway as a potential target for structure-based design of antibacterial agents.

  title={Bacterial lipoprotein biosynthetic pathway as a potential target for structure-based design of antibacterial agents.},
  author={Jie Xia and Bo Feng and Gang Wen and Wenjie Xue and Guixing Ma and Hongmin Zhang and Song Wu},
  journal={Current medicinal chemistry},
BACKGROUND Antibiotic resistance is currently a serious problem for global public health. To this end, discovery of new antibacterial drugs that interact with novel targets is important. The biosynthesis of lipoproteins is vital to bacterial survival and its inhibitors have shown efficacy against a range of bacteria, thus bacterial lipoprotein biosynthetic pathway is a potential target. METHODS At first, the literature that covered the basic concept of bacterial lipoprotein biosynthetic… 
10 Citations
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