Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.

@article{Heine1999BacterialLI,
  title={Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.},
  author={Holger Heine and Russell L. Delude and Brian G Monks and Terje Espevik and Douglas T Golenbock},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 30},
  pages={21049-55}
}
CD14-transfected Chinese hamster ovary K1 fibroblasts (CHO/CD14) respond to lipopolysaccharide (LPS) by metabolizing arachidonic acid and with translocation of NF-kappaB to the nucleus. Although previous experiments failed to identify the production of tumor necrosis factor-alpha and interleukin (IL)-1beta by CHO/CD14 cells, LPS did induce the expression of IL-6 mRNA and the subsequent release of the IL-6 protein. To identify additional LPS-inducible genes, a cDNA library derived from LPS… CONTINUE READING

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