Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats.

@article{Reddy2006BacterialLO,
  title={Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats.},
  author={Mallikarjuna M Reddy and Suraneni V K Mahipal and Jagu Subhashini and Madhava C. Reddy and Karnati R Roy and Gorla Venkateswara Reddy and P. Ravikaladhar Reddy and Pallu Reddanna},
  journal={Reproductive toxicology},
  year={2006},
  volume={22 3},
  pages={
          493-500
        }
}
Microbial infections, localized as well as systemic, are known to cause transitive or permanent male infertility. However, the mechanisms of infection-induced infertility are largely unknown. Earlier reports showed that steroidogenesis and spermatogenesis are affected during bacterial lipopolysaccharide (LPS)-induced acute inflammation. The present study used an LPS rat model to investigate the role of oxidative stress in spermatogenesis. Intraperitoneal administration of bacterial LPS (5mg/kg… CONTINUE READING

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