Bacterial killing by Mytilus hemocyte monolayers as a model for investigating the signaling pathways involved in mussel immune defence.

@article{Canesi2002BacterialKB,
  title={Bacterial killing by Mytilus hemocyte monolayers as a model for investigating the signaling pathways involved in mussel immune defence.},
  author={Laura Canesi and Alfonso Scarpato and Michele Betti and Caterina Ciacci and Carla Pruzzo and Gabriella Gallo},
  journal={Marine environmental research},
  year={2002},
  volume={54 3-5},
  pages={547-51}
}
The signaling pathways involved in mussel immune defence were investigated utilizing a model of killing of Escherichia coli by Mytilus galloprovincialis hemocytes in a co-culture setting. In particular, the role played by different mitogen activated protein kinases (MAPKs) and by the production of eicosanoids were investigated utilising specific cell permeant, pharmacological enzyme inhibitors. Hemocyte pretreatment with the p38 MAPK inhibitor SB203580 significantly reduced bacterial killing… CONTINUE READING
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