Bacterial genome variability and its impact on vaccine design.

@article{Telford2008BacterialGV,
  title={Bacterial genome variability and its impact on vaccine design.},
  author={John L. Telford},
  journal={Cell host & microbe},
  year={2008},
  volume={3 6},
  pages={408-16}
}
The majority of currently available successful vaccines induce host responses against antigens that are highly conserved in the targeted pathogens. The diphtheria, tetanus, and pertussis vaccines confer protection by inducing neutralizing antibodies to the conserved bacterial toxins that are the major virulence factors. The Hemophilus influenzae B vaccine induces responses to conserved epitopes in the sugar structure of the bacterial capsular polysaccharide. However, the efficacy of more… CONTINUE READING
Highly Cited
This paper has 66 citations. REVIEW CITATIONS

3 Figures & Tables

Topics

Statistics

010202009201020112012201320142015201620172018
Citations per Year

67 Citations

Semantic Scholar estimates that this publication has 67 citations based on the available data.

See our FAQ for additional information.