Bacterial genome variability and its impact on vaccine design.

  title={Bacterial genome variability and its impact on vaccine design.},
  author={John L. Telford},
  journal={Cell host & microbe},
  volume={3 6},
The majority of currently available successful vaccines induce host responses against antigens that are highly conserved in the targeted pathogens. The diphtheria, tetanus, and pertussis vaccines confer protection by inducing neutralizing antibodies to the conserved bacterial toxins that are the major virulence factors. The Hemophilus influenzae B vaccine induces responses to conserved epitopes in the sugar structure of the bacterial capsular polysaccharide. However, the efficacy of more… CONTINUE READING
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