Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions

  title={Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions},
  author={Wolfgang Florian Fricke and David A. Rasko},
  journal={Nature Reviews Genetics},
The potential of bacterial whole-genome sequencing (WGS) to complement existing diagnostic infrastructures in clinical microbiology has been shown in proof-of-principle examples and extensively discussed. However, less attention has been drawn to bioinformatic challenges that are associated with the clinical adoption of WGS-based molecular diagnostics. This Perspective article discusses questions that are related to standard operating procedures, computational resource management, and data… CONTINUE READING
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A pilot study of rapid whole-genome sequencing for the investigation of a Legionella outbreak

  • S Reuter
  • BMJ Open 3,
  • 2013

Metagenomic analysis of tuberculosis in a mummy

  • Chan, Z J.
  • N. Engl. J. Med
  • 2013

Next generation genomics: world map of high-throughput sequencers [online],

  • J. Hadfield, N. J. Loman
  • 2013

Short-read alignment on the Raspberry Pi

  • D. Swan
  • Eridanusdotnet [online],
  • 2013

Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC

  • Harrison, M E.
  • EMBO Mol. Med
  • 2013

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