Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions

@article{Fricke2014BacterialGS,
  title={Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions},
  author={Wolfgang Florian Fricke and David A. Rasko},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={49-55}
}
The potential of bacterial whole-genome sequencing (WGS) to complement existing diagnostic infrastructures in clinical microbiology has been shown in proof-of-principle examples and extensively discussed. However, less attention has been drawn to bioinformatic challenges that are associated with the clinical adoption of WGS-based molecular diagnostics. This Perspective article discusses questions that are related to standard operating procedures, computational resource management, and data… CONTINUE READING
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