Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection.

@article{Wickham2006BacterialGD,
  title={Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection.},
  author={Mark E. Wickham and Claudia Lupp and Mariola Mascarenhas and Alejandra Mateo V{\'a}zquez and Brian K Coombes and Nat F. Brown and Bryan A. Coburn and Wanyin Deng and Jos{\'e} Luis Puente and Mohamed Karmali and Brett B. Finlay},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={194 6},
  pages={819-27}
}
Although O157:H7 Shiga toxin-producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of HUS that are underdetected by current diagnostic approaches. Because Shiga toxin is necessary but not sufficient to cause HUS, identifying the virulence determinants that predict severe disease after non-O157 STEC infection is of paramount importance. Disease caused by O157:H7 STEC has been associated… CONTINUE READING

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