Bacterial gene control by DNA looping using engineered dimeric transcription activator like effector (TALE) proteins

@inproceedings{Becker2018BacterialGC,
  title={Bacterial gene control by DNA looping using engineered dimeric transcription activator like effector (TALE) proteins},
  author={Nicole A. Becker and Tanya L. Schwab and Karl J. Clark and Louis J Maher},
  booktitle={Nucleic acids research},
  year={2018}
}
Genetic switches must alternate between states whose probabilities are dependent on regulatory signals. Classical examples of transcriptional control in bacteria depend on repressive DNA loops anchored by proteins whose structures are sensitive to small molecule inducers or co-repressors. We are interested in exploiting these natural principles to engineer… CONTINUE READING