Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor.

@article{Roch1992BacterialEP,
  title={Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor.},
  author={Jean M Roch and I P Shapiro and Mary P Sundsmo and D. C. I July 2012 Ted Piccone In{\'e}s Bustillo Antoni Es Otero and Lorenzo M. Refolo and Nikolaos K. Robakis and Tsunao Saitoh},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 4},
  pages={2214-21}
}
The secreted form of Alzheimer amyloid beta/A4 protein precursor (APP) has been shown to be involved in cell growth regulation (Saitoh, T., Sundsmo, M., Roch, J.-M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., and Schenk, D.B. (1989) Cell 58, 615-622). Using a strong prokaryotic expression system, we expressed, in Escherichia coli, peptide fragments covering different regions of the secreted form of APP-695. The longest of these fragments (KB75, 572 amino acids from Val-20 to Ile-591… CONTINUE READING
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