Bacterial endotoxin sensitizes the immature brain to hypoxic–ischaemic injury

@article{Eklind2001BacterialES,
  title={Bacterial endotoxin sensitizes the immature brain to hypoxic–ischaemic injury},
  author={Saskia Eklind and Carina Mallard and A L Leverin and Eric Gilland and Klas Blomgren and Inger Mattsby‐Baltzer and Henrik Hagberg},
  journal={European Journal of Neuroscience},
  year={2001},
  volume={13}
}
Epidemiological studies show a markedly increased risk of cerebral palsy following the combined exposure of infection and birth asphyxia. However, the underlying mechanisms of this increased vulnerability remain unclear. We have examined the effects of a low dose of bacterial endotoxin on hypoxic–ischaemic injury in the immature brain of rats. Bacterial endotoxin (lipopolysaccharide 0.3 mg/kg) was administered to 7‐day‐old rats 4 h prior to unilateral hypoxia–ischaemia and the neurological… 
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Lipopolysaccharide-induced inflammation and perinatal brain injury.
Antenatal brain injury and prospects for neuroprotection
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Acute fetal hypoxia: the modulating effect of infection.
Infection and fetal neurologic injury
  • A. Ugwumadu
  • Medicine, Biology
    Current opinion in obstetrics & gynecology
  • 2006
TLDR
This review will discuss the complex interaction between fetal inflammatory response and neurotoxicity, and focus on the clinical implications of the synergistic interaction between infection/inflammation and hypoxia–ischaemia.
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