Bacterial endotoxin both enhances and inhibits the toxicity of Shiga-like toxin II in rabbits and mice.

@article{Barrett1989BacterialEB,
  title={Bacterial endotoxin both enhances and inhibits the toxicity of Shiga-like toxin II in rabbits and mice.},
  author={Timothy J. Barrett and Morris E Potter and ipke. wachsmuth},
  journal={Infection and immunity},
  year={1989},
  volume={57 11},
  pages={3434-7}
}
The ability of bacterial lipopolysaccharide (LPS) to enhance the toxicity of Shiga-like toxin II (SLT-II) was investigated in rabbits and mice. Rabbits were continuously infused with 0.5 50% lethal dose (LD50) of SLT-II per day. Rabbits that received a 30-micrograms/kg dose of LPS (0.02 LD50) on day 3 of infusion were significantly more likely to die than were rabbits receiving SLT-II only. Rabbits receiving SLT-II and a lower dose of LPS (3 micrograms/kg) did not die but lost an average 3.3… CONTINUE READING
22 Citations
17 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

The histopathology of the hemolytic uremic syndrome associated with verocytotoxin - producing Escherichia coli infections

  • L. W. Riley, R. S. Remis, +9 authors M. L. Cohen
  • Hum . Pathol .
  • 1988

Inhibition of elongation factor 1-dependent aminoacyltRNA binding to ribosomes by Shiga-like toxin I (VT1) from Escherichia coli 0157:H7 and by Shiga toxin

  • K. Igarashi, T. Ogasawara, K. Ito, T. Yutsudo, Y. Takeda
  • FEMS Microbiol . Lett .
  • 1987
1 Excerpt

The mode of action of Shiga toxin on peptide elongation of eukaryotic protein synthesis

  • K. Igarashi, T. Yutsudo, N. Nakabayashi, Y. Takeda
  • Biochem . J .
  • 1987

Mechanisms of endotoxin tolerance , p . 359 - 401

  • L. B. Hinshaw
  • The handbook of endotoxin , vol . 2…
  • 1985

Similar Papers

Loading similar papers…