Bacterial endotoxin both enhances and inhibits the toxicity of Shiga-like toxin II in rabbits and mice.

  title={Bacterial endotoxin both enhances and inhibits the toxicity of Shiga-like toxin II in rabbits and mice.},
  author={Timothy J. Barrett and Morris E Potter and ipke. wachsmuth},
  journal={Infection and immunity},
  volume={57 11},
The ability of bacterial lipopolysaccharide (LPS) to enhance the toxicity of Shiga-like toxin II (SLT-II) was investigated in rabbits and mice. Rabbits were continuously infused with 0.5 50% lethal dose (LD50) of SLT-II per day. Rabbits that received a 30-micrograms/kg dose of LPS (0.02 LD50) on day 3 of infusion were significantly more likely to die than were rabbits receiving SLT-II only. Rabbits receiving SLT-II and a lower dose of LPS (3 micrograms/kg) did not die but lost an average 3.3… CONTINUE READING
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