Bacterial efflux pump inhibitors from natural sources.

@article{Stavri2007BacterialEP,
  title={Bacterial efflux pump inhibitors from natural sources.},
  author={Michael Stavri and Laura J. V. Piddock and Simon Gibbons},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={59 6},
  pages={
          1247-60
        }
}
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and, more recently, in mycobacteria. Efflux pumps are able to extrude structurally diverse… 
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An update of newly discovered efflux pump inhibitors with plant-based origin against bacterial strains of concern and the hurdles of clinical implementation are discussed.
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