Bacterial dehalogenases: biochemistry, genetics, and biotechnological applications.

@article{Fetzner1994BacterialDB,
  title={Bacterial dehalogenases: biochemistry, genetics, and biotechnological applications.},
  author={Susanne Fetzner and Franz Lingens},
  journal={Microbiological reviews},
  year={1994},
  volume={58 4},
  pages={641-85}
}
This review is a survey of bacterial dehalogenases that catalyze the cleavage of halogen substituents from haloaromatics, haloalkanes, haloalcohols, and haloalkanoic acids. Concerning the enzymatic cleavage of the carbon-halogen bond, seven mechanisms of dehalogenation are known, namely, reductive, oxygenolytic, hydrolytic, and thiolytic dehalogenation; intramolecular nucleophilic displacement; dehydrohalogenation; and hydration. Spontaneous dehalogenation reactions may occur as a result of… CONTINUE READING

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