Bacterial deception of MAIT cells in a cloud of superantigen and cytokines

@inproceedings{Sandberg2017BacterialDO,
  title={Bacterial deception of MAIT cells in a cloud of superantigen and cytokines},
  author={Johan K Sandberg and Anna Norrby-Teglund and Edwin Leeansyah},
  booktitle={PLoS biology},
  year={2017}
}
The bacterium Staphylococcus aureus is an important cause of the life-threatening condition toxic shock syndrome in humans. Bacterial toxins known as superantigens (SAgs) generate this illness by acting as broad activators of a substantial fraction of all T lymphocytes, bypassing the normally highly stringent T-cell receptor antigen specificity to cause a systemic inflammatory cytokine storm in the host. In a new study, Shaler et al. found that immune cells called mucosa-associated invariant T… CONTINUE READING
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