Bacterial cytotoxins: targeting eukaryotic switches

  title={Bacterial cytotoxins: targeting eukaryotic switches},
  author={Klaus Aktories and Joseph T. Barbieri},
  journal={Nature Reviews Microbiology},
Many bacterial cytotoxins act on eukaryotic cells by targeting the regulators that are involved in controlling the cytoskeleton or by directly modifying actin, with members of the Rho GTPase family being particularly important targets. The actin cytoskeleton, and especially the GTPase 'molecular switches' that are involved in its control, have crucial functions in innate and adaptive immunity, and have pivotal roles in the biology of infection. In this review, we briefly discuss the role of the… CONTINUE READING