Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2.

@article{Sadikot2007BacterialCO,
  title={Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2.},
  author={Ruxana T. Sadikot and Heng Zeng and Anser C. Azim and Myungsoo Joo and Sudhansu K Dey and Richard M Breyer and Rhonda S. Peebles and Timothy S. Blackwell and John W Christman},
  journal={European journal of immunology},
  year={2007},
  volume={37 4},
  pages={1001-9}
}
Prostanoids generated by COX-2 are involved in the regulation of inflammation but their exact role in the innate immune response has not been defined. We investigated whether COX-2 is involved in host defense against Pseudomonas aeruginosa pneumonia. In vitro studies, in a macrophage cell line, showed that cytotoxic strain of P aeruginosa (PA103) induced significant COX-2 protein expression and enzymatic function. In vivo data showed that infection with PA103 increased COX-2 protein production… CONTINUE READING
45 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…