Bacterial chromatin organization by H-NS protein unravelled using dual DNA manipulation

  title={Bacterial chromatin organization by H-NS protein unravelled using dual DNA manipulation},
  author={R. T. Dame and M. C. Noom and G. Wuite},
  • R. T. Dame, M. C. Noom, G. Wuite
  • Published 2006
  • Biology, Medicine
  • Nature
  • Both prokaryotic and eukaryotic organisms contain DNA bridging proteins, which can have regulatory or architectural functions. The molecular and mechanical details of such proteins are hard to obtain, in particular if they involve non-specific interactions. The bacterial nucleoid consists of hundreds of DNA loops, shaped in part by non-specific DNA bridging proteins such as histone-like nucleoid structuring protein (H-NS), leucine-responsive regulatory protein (Lrp) and SMC (structural… CONTINUE READING
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