Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously

@inproceedings{Cho2016BacterialCW,
  title={Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously},
  author={Hongbaek Cho and Carl N Wivagg and Mrinal Kapoor and Zachary Barry and Patricia D A Rohs and Hyunsuk Suh and Jarrod A. Marto and Ethan C Garner and Thomas G Bernhardt},
  booktitle={Nature Microbiology},
  year={2016}
}
Multi-protein complexes organized by cytoskeletal proteins are essential for cell wall biogenesis in most bacteria. Current models of the wall assembly mechanism assume that class A penicillin-binding proteins (aPBPs), the targets of penicillin-like drugs, function as the primary cell wall polymerases within these machineries. Here, we use an in vivo cell wall polymerase assay in Escherichia coli combined with measurements of the localization dynamics of synthesis proteins to investigate this… CONTINUE READING
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