Bacterial biosynthesis and maturation of the didemnin anti-cancer agents.

@article{Xu2012BacterialBA,
  title={Bacterial biosynthesis and maturation of the didemnin anti-cancer agents.},
  author={Ying Xu and Roland D Kersten and Sang-Jip Nam and Liang Lu and Abdulaziz M. Al-Suwailem and Huajun Zheng and William Fenical and Pieter C. Dorrestein and Bradley S Moore and Pei-Yuan Qian},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 20},
  pages={8625-32}
}
The anti-neoplastic agent didemnin B from the Caribbean tunicate Trididemnum solidum was the first marine drug to be clinically tested in humans. Because of its limited supply and its complex cyclic depsipeptide structure, considerable challenges were encountered during didemnin B's development that continue to limit aplidine (dehydrodidemnin B), which is currently being evaluated in numerous clinical trials. Herein we show that the didemnins are bacterial products produced by the marine… CONTINUE READING

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