Bacterial biofilms: a common cause of persistent infections.

@article{Costerton1999BacterialBA,
  title={Bacterial biofilms: a common cause of persistent infections.},
  author={J. Costerton and P. Stewart and E. Greenberg},
  journal={Science},
  year={1999},
  volume={284 5418},
  pages={
          1318-22
        }
}
Bacteria that attach to surfaces aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. Studies of biofilms have revealed differentiated, structured groups of cells with community properties. Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Mechanisms of adhesion by oral bacteria.
TLDR
The potential roles of adherence-relevant molecules are discussed in the context of the dynamic nature of the oral econiche in terms of adhesin-receptor cognate pairs on genetically distinct cells. Expand
Prevention and control of bacterial infections associated with medical devices.
TLDR
The authors suggest that this bioelectric technology can readily be used to enhance the preimplantation sterilization of medical devices by biocides and by electrically enhanced penetration of antibiotics to kill the biofilm bacteria that form the inherently resistant nidus of chronic device related infections. Expand
Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin
TLDR
Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated P. aeruginosa mutant noninducible for the expression of beta-lactamase did not detect piperacillinoic acid. Expand
Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms
TLDR
It is suggested that transport limitations may be an important factor in the antimicrobial resistance of biofilm bacteria and that ATR/FT-IR spectrometry may be used to follow the time course of antimicrobial action in biofilms in situ. Expand
Tobramycin resistance of Pseudomonas aeruginosa cells growing as a biofilm on urinary catheter material
TLDR
Data indicate that growth within thick adherent biofilms confers a measure of tobramycin resistance on cells of P. aeruginosa. Expand
Mathematical model of β-lactam penetration into a biofilm of Pseudomonas aeruginosa while undergoing simultaneous inactivation by released β-lactamases
TLDR
It is shown here that lysis of cells in the surface layers of a film could have an important protective effect on the viability of underlying bacteria, especially in thick biofilms. Expand
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
TLDR
The isolation and characterization of mutants of Pseudomonas aeruginosa PA14 defective in the initiation of biofilm formation on an abiotic surface, polyvinylchloride (PVC) plastic are reported and evidence that microcolonies form by aggregation of cells present in the monolayer is presented. Expand
In Vitro and In Vivo Activities of Levofloxacin against Biofilm-Producing Pseudomonas aeruginosa
  • H. Ishida, Yoshihisa Ishida, Y. Kurosaka, T. Otani, Kenichi Sato, Hiroyuki Kobayashi
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1998
TLDR
The significant role of levofloxacin in therapy of biofilm bacterium-associated infectious diseases is suggested and experimental pneumonia in guinea pigs, in which the biofilm mode of growth of the strain was observed in the lung, is suggested. Expand
Antibiotic interaction and diffusion through alginate and exopolysaccharide of cystic fibrosis-derived Pseudomonas aeruginosa.
TLDR
The interaction of five anti-pseudomonas antibiotics with both commercial and pseudomonas alginates was studied by investigation of their binding and diffusion characteristics, with strong aminoglycoside binding to alginate reduced, but not eliminated by the presence of physiological concentrations of salts. Expand
A Sandwich Cup Method for the Penetration Assay of Antimicrobial Agents through Pseudomonas Exopolysaccharides
TLDR
The results suggest that the microenvironment at the infection site could greatly influence drug penetration through biofilms in vivo. Expand
...
1
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