Bacterial biofilms: a common cause of persistent infections.

@article{Costerton1999BacterialBA,
  title={Bacterial biofilms: a common cause of persistent infections.},
  author={J. Costerton and P. Stewart and E. P. Greenberg},
  journal={Science},
  year={1999},
  volume={284 5418},
  pages={
          1318-22
        }
}
  • J. Costerton, P. Stewart, E. P. Greenberg
  • Published 1999
  • Medicine, Biology
  • Science
  • Bacteria that attach to surfaces aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. Studies of biofilms have revealed differentiated, structured groups of cells with community properties. Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to… CONTINUE READING
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    References

    SHOWING 1-10 OF 42 REFERENCES
    Mechanisms of adhesion by oral bacteria.
    • 386
    Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin.
    • 169
    • PDF
    Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms.
    • 318
    • PDF