Bacterial and mammalian cell mutagenicity of four optically active bay-region 10,11-diol-8,9-epoxides of the nitrogen heterocycle dibenz[a,h]acridine.

@article{Chang1993BacterialAM,
  title={Bacterial and mammalian cell mutagenicity of four optically active bay-region 10,11-diol-8,9-epoxides of the nitrogen heterocycle dibenz[a,h]acridine.},
  author={Richard L. Chang and Sabrina Battista and C. Q. Wong and Sushil Kumar and Panna L Kole and Harish C. Sikka and Suresh K. Balani and Donald M. Jerina and Allan H. Conney and Alexander W. Wood},
  journal={Carcinogenesis},
  year={1993},
  volume={14 11},
  pages={2233-7}
}
The mutagenic activities of the enantiomers of the diastereomeric pair of bay-region 10,11-diol-8,9-epoxides of dibenz[a,h]acridine (DB[a,h]ACR) were evaluated in histidine-dependent strains of Salmonella typhimurium and in cultured Chinese hamster V79 cells. In strains TA98 and TA100 of S.typhimurium, the (-)-[8S,9R,10R,11S] diol-epoxide was the most… CONTINUE READING