Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits.

@article{SmithSwintosky1996BacterialAM,
  title={Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits.},
  author={Virginia L. Smith-Swintosky and Philipp J. Kraemer and Annadora J. Bruce and N McCants and Atsushi Maki and Russell W. Brown and Magdalena Alcal{\'a} and Y Goodman and John T. Slevin and Mark P. Mattson},
  journal={Experimental neurology},
  year={1996},
  volume={141 2},
  pages={287-96}
}
Studies of human patients with temporal lobe epilepsy and animal models of epilepsy have established relationships between seizures, excitotoxic hippocampal damage, and memory impairment. We report that bacterial alkaloids, recently shown to mimic actions of neurotrophic factors in cell culture, attenuate seizure-induced damage to hippocampal neurons and memory impairment in adult rats when administered subcutaneously. Intrahippocampal administration of convulsant doses of kainic acid (KA) to… CONTINUE READING
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