Bacterial adaptation through distributed sensing of metabolic fluxes

@inproceedings{Kotte2010BacterialAT,
  title={Bacterial adaptation through distributed sensing of metabolic fluxes},
  author={Oliver Kotte and Judith B. Zaugg and Matthias Heinemann},
  booktitle={Molecular systems biology},
  year={2010}
}
The recognition of carbon sources and the regulatory adjustments to recognized changes are of particular importance for bacterial survival in fluctuating environments. Despite a thorough knowledge base of Escherichia coli's central metabolism and its regulation, fundamental aspects of the employed sensing and regulatory adjustment mechanisms remain unclear. In this paper, using a differential equation model that couples enzymatic and transcriptional regulation of E. coli's central metabolism… CONTINUE READING
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