Bacterial Virulence Proteins as Tools to Rewire Kinase Pathways in Yeast and Immune Cells

  title={Bacterial Virulence Proteins as Tools to Rewire Kinase Pathways in Yeast and Immune Cells},
  author={Ping Wei and Wilson W. Wong and Jason Sun-hyung Park and Ethan E. Corcoran and Sergio Peisajovich and James J. Onuffer and Arthur Weiss and Wendell A Lim},
Bacterial pathogens have evolved specific effector proteins that, by interfacing with host kinase signalling pathways, provide a mechanism to evade immune responses during infection. Although these effectors contribute to pathogen virulence, we realized that they might also serve as valuable synthetic biology reagents for engineering cellular behaviour. Here we exploit two effector proteins, the Shigella flexneri OspF protein and Yersinia pestis YopH protein, to rewire kinase-mediated responses… CONTINUE READING
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