Bacterial Toxins for Oncoleaking Suicidal Cancer Gene Therapy.


For suicide gene therapy, initially prodrug-converting enzymes (gene-directed enzyme-producing therapy, GDEPT) were employed to intracellularly metabolize non-toxic prodrugs into toxic compounds, leading to the effective suicidal killing of the transfected tumor cells. In this regard, the suicide gene therapy has demonstrated its potential for efficient… (More)
DOI: 10.1007/978-3-319-42934-2_7


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